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April 15, 2002
OLYMPUS OPTICAL CO., LTD.
TERUMO CORPORATION
The first development of minimally invasive treatment devices
by Olympus and Terumo : Guidewire for Digestive Endoscopy
New Product "Disposable Guidewire"
Disposable Guidewire
"Disposable Guidewire"
Olympus Optical Co., Ltd. ( President : Tsuyoshi Kikukawa, hereinafter called "Olympus" ) and Terumo Corporation ( President : Takashi Wachi, hereinafter called "Terumo" ) have developed guidewire *1 for digestive endoscopy of the pancreas and bile duct as the first project after entering into an alliance agreement in the field of medical equipment in April 2001. "Disposable Guidewire", which will be targeted at medical institutions, will be initially launched in Japan on April 18th and then gradually launched onto the global market. The 2002 target sales figure is 400 million yen.
*1 Guidewire
A thin metal wire around 1 mm in diameter which is used to guide a catheter or other device to the target site in the body.
Guidewire for digestive endoscopy is passed through an endoscope which is introduced via the mouth to the duodenum. During the removal of biliary stones, for instance, the target site can be easily reached from the major duodenal papilla, the point of opening of the bile duct into the duodenum, by attaching a papillotomy knife *2, balloon catheter, or other device to the guidewire. During the last 10 years or so in Europe and the United States and 3 or 4 years in Japan, guidewire has become an important tool in all therapeutic procedures of the pancreas and bile duct in which it plays a fundamental life-saving role.
*2 Papillotomy knife
An implement used to make an incision in the major duodenal papilla under endoscopy. The papillotomy knife is an electrocautery inserted via a guidewire in an endoscope positioned in the duodenum and is used to make an incision in the major duodenal papilla.
Disposable Guidewire inserted via a papillotomy knife passed through an endoscope
"Disposable Guidewire inserted via a papillotomy knife
passed through an endoscope"
Background of Market Entry
In the development of "Disposable Guidewire" planned and designed by both companies, the product will be developed and manufactured by Terumo and marketed by Olympus. This strategy makes maximum use of the strengths of Olympus in the field of endoscopy and Terumo in guidewire - domains in which both companies have highly advanced technology and a large share in the world market.

Olympus will attempt an aggressive marketing and expansion campaign by introducing internationally competitive products on the world market of guidewire for digestive endoscopy, which capitalize on both companies' strengths. In addition, Olympus and Terumo will make a positive contribution to the next generation of medical care by developing minimally invasive diagnostic and treatment instruments which will reduce the pain and suffering of patients in the field of gastroenterology as well as cardiovascular surgery and urology.
* "Disposable Guidewire" will be exhibited at the 63rd Annual Meeting of the Japan Gastroenterological Endoscopy Society ( President : Dr. Masayuki Fujino, 1st Department of Medicine, Yamanashi Medical University ) to be held in Apio Kofu ( Kofu City, Yamanashi Prefecture, Japan ) from April 18 to 20.
Main Features
1. Hydrophilic-coated 10-cm tip
A 10-cm section of the tip of the guidewire has a hydrophilic polymer coating which increases its slipperiness when in contact with body fluids or water. The lubricious coating aims to improve delivery of the guidewire to the target lesion site and smooth passage of the instrument through stenotic regions.

2. Visual marker
The tip of the guidewire has a striped visual marker by which the movement of the guidewire during endoscopic treatments can be easily verified. It enables the position of the guidewire, a critical factor in difficult therapeutic procedures of the pancreas and bile duct, to be confirmed on endoscopic images.

3. Super-elastic alloy with good trackability at insertion
By using a super-elastic alloy which utilizes Terumo's material processing technology, an appropriate level of elasticity is ensured for easy insertion in stenotic regions, despite being a thin, soft material.

4. Good imaging capacity
By mixing the plastic layer tube of the guidewire with contrast medium, the location of the guidewire can be easily confirmed on X-ray.

About Olympus Optical Co., Ltd.
Head Office : Shinjuku Monolith, 3-1, Nishi-shinjuku 2-chome,
Shinjuku-ku, Tokyo
President : Tsuyoshi Kikukawa
Establishment : 1919
Paid-in Capital : 40,832 millions of yen ( End of March, 2001 )
Consolidated Net Sales : 466,704 millions of yen ( End of March, 2001 )
Number of Employees : 4,282 ( End of March, 2001 )
Main Business : Manufacturing and sales of equipment and devices relating to the fields of medical and healthcare, imaging and information, and industrial applications :
Medical endoscopes, microscopes, clinical analyzers, reagents, cameras, digital cameras, microcassette and IC recorders magneto-optical disc drives, printers, barcode scanners, industrial endoscopes, measurers and motors; others.
 
Olympus has developed fiberscopes and videoscopes with which internal organs can be directly observed since the company developed the first photogastroscope in 1950. Today we are expanding our business including the development of instruments and devices for medical treatment, as well as those for diagnosis. Olympus has the largest market share and the most advanced technology of endoscopes in the world. The company is contributing to the treatment of diseases and the early detection of cancers.

About Terumo Corporation
Head Office : 44-1, Hatagaya 2-chome, Shibuya-ku, Tokyo
President : Takashi Wachi
Establishment : 1921
Paid-in Capital : 38,716 millions of yen ( End of March, 2001 )
Consolidated Net Sales : 176,049 millions of yen ( End of March, 2001 )
Number of Employees : 4,163 ( End of March, 2001 )
Main Business : Manufacture and sales of medical products, nutritional food supplement, blood bags, disposable medical devices, oxygenetor systems, dialyzers, artificial organs, medical electronic and digital thermometers, etc.
 
Terumo has a high market share of disposable medical devices, nutriment alignments, and I.V. solution in Japan and overseas. The company has the largest market share of guidewires for angiography and treatment in the world. We have a high level of technical expertise with respect to our advanced medical instruments such as interventional catheters and stents, and oxygenator systems.
*Olympus Optical Co., Ltd. was changed to OLYMPUS CORPORATION as of October 1, 2003.
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